Taxiva®
(Telmisartan & Amlodipine Besilate)
40/5 mg & 80/10mg bilayer tablets
COMPOSITION:
For the 40/5mg Tablets; each uncoated bilayer tablet contains: Amlodipine Besilate BP Equivalent to Amlodipine 5 mg, Telmisartan BP 40 mg and Excipients Q.S. and for the 80/10mg Tablets, each uncoated bilayer tablet contains: Amlodipine Besilate BP Equivalent to Amlodipine 10 mg, Telmisartan BP 80 mg and Excipients Q.S respectively.
PHARMACOLOGY:
Pharmacodynamic: TAXIVA ® tablets have been shown to be effective in lowering blood pressure. TAXIVA ® is a combination of two drugs with antihypertensive properties: a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker), amlodipine besylate, and an angiotensin II receptor blocker, telmisartan.
Both telmisartan and amlodipine lower blood pressure by reducing peripheral resistance but through complementary mechanisms.
Indications
TAXIVA ® (telmisartan/amlodipine) Tablets are indicated for the treatment of hypertension, alone or with other antihypertensive agents to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
Dosage and Administration
Telmisartan is an effective treatment of hypertension in once daily doses of 20 to 80 mg while amlodipine is effective in doses of 2.5 to 10 mg. Dosage must be individualized and may be increased after at least 2 weeks. Most of the antihypertensive effect is apparent within 2 weeks and maximal reduction is generally attained after 4 weeks. The maximum recommended dose of TAXIVA ® tablets is 80/10 mg once daily. TAXIVA® may be taken with or without food.
Contraindications
TAXIVA ® tablets are contraindicated in patients with known hypersensitivity (e.g., anaphylaxis or angioedema) to telmisartan, amlodipine, or any other component of this product. Do not co-administer aliskiren with TAXIVA in patients with diabetes.
Storage and Handling Instrutions
Do not store above 30 oC, protected from moisture, store in the original package. Do not remove from strip until immediately before administration.
Keep all medicines out of reach of children.Availability
On prescription only.
Packaging Information
3 X 10 Alu Alu Pack
Tripine® Retard
(Nifedipine Retard Tablets 20 mg)
COMPOSITION:
Each film coated tablet contains: Nifedipine BP; 20 mg, Excipients; Q.S.
PHARMACOLOGICAL CLASSIFICATION:
Nifedipine is a calcium antagonist of the 1, 4-dihydropyridine type. Tripine® Retard 20 mg tablet is formulated to achieve controlled delivery of nifedipine in a release profile sufficient to enable once-daily administration to be effective in clinical use. In hypertension, the main action of nifedipine is to cause peripheral vasodilatation and thus reduce peripheral resistance.
Indications
For the treatment of mild to moderate hypertension. It is also used for the prophylaxis of chronic stable angina pectoris either as monotherapy or in combination with a beta-blocker.
Dosage and Administration
Oral use:The tablets should be swallowed whole with a glass of water, either with or without food. The tablets should be taken at approximately 24-hour intervals, i.e. at the same time each day, preferably during the morning. Nifedipine Retard 20 mg tablets must be swallowed whole; under no circumstance should they be bitten, chewed or broken up.
Nifedipine Retard 20 mg should not be taken with grapefruit juice. It inhibits the oxidative degradation of nifedipine and so elevated plasma levels of nifedipine may occur.Storage and Handling Instrutions
Store in cool & dry place below 30oC, away from sunlight. Keep all medicines out of reach of children
Availability
On prescription only.
Packaging Information
20mg tablets in Alu-Alu strips of 10’s x 10 in a box.